By C. Wüster, T. Cowell

ISBN-10: 0585441014

ISBN-13: 9780585441016

ISBN-10: 3805571852

ISBN-13: 9783805571852

Complement factor: Hormone examine 2000, Vol. fifty four, No. 1

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Extra info for Analytical Methods in Clinical Osteology: Useful Predictors of Long-Term Outcomes or a Waste of Time and Money? 4th Kigs Kims Expert Meeting on Growth ... Taormina, November (Hormone Research)

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For the analysis of fracture rates, radiological documentation was sought for each patient who had a fracture. Data from KIMS patients were compared with age- and sex-matched data from EVOS [15]. Both KIMS and EVOS use the same question to determine fracture history. At the time of this analysis, fracture data were available from 2,024 patients (1,079 men, 945 women), of whom 1,518 had adult-onset GHD and 506 had child- Fracture Rates in Patients with GHD Results The prevalence of fractures in the KIMS subgroup of 264 patients was similar to the prevalence of fractures in all KIMS patients.

Overall, the results of BMD measurements in elderly patients may not reflect the general situation in individuals with adult-onset GHD. One study involving patients of various ages with adult-onset GHD has shown that bone mineral content was lower than expected [7]. In considering the effects of GHD in individuals with adult-onset disease, it is important to realize that the duration of untreated hypogonadism will influence bone mass. 32 Horm Res 2000;54(suppl 1):31–35 Although there is much evidence to suggest that untreated GHD leads to a reduction in bone mass, few assessments of fracture rate in patients with GHD have been performed.

This paradigm incited intensive cell and molecular research on the effector cells of bone, and it still lingers today [8, 13, 14]. constitute the main goal of its biological mechanisms. The mechanical function would dominate other functions, such as homeostasis, and primary disorders in the adaptive mechanisms of a bone would cause failures to achieve that competence. The Utah Paradigm Because many of the tissue-level mechanisms of bone and their functions (termed the ‘nephron equivalents’ of bone), were not discovered until after 1964, the 1960 paradigm of skeletal physiology could not take these factors into account.

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Analytical Methods in Clinical Osteology: Useful Predictors of Long-Term Outcomes or a Waste of Time and Money? 4th Kigs Kims Expert Meeting on Growth ... Taormina, November (Hormone Research) by C. Wüster, T. Cowell


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